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細菌劫持免疫細胞

文章來源:中國科學報 宗華   發布時間:2019-04-11  【字號:     】  

  沙門氏菌可劫持免疫細胞,并利用它們在體內傳播。針對小鼠細胞進行的實驗表明,這種細菌通過擾亂腸道內的電信號達到這一目的。相關成果日前發表于美國《科學公共圖書館·綜合》。

  人類腸道擁有小電場。這是由鉀離子和氯離子等帶電離子進出腸道細胞造成的。諸如食物中毒等沙門氏菌感染會擾亂電場,因為它們會破壞警告身體免疫細胞前來清理這些“臟東西”的細胞。

  通常,免疫系統擅長將感染限制在腸道內。但有時沙門氏菌通過巨噬細胞(一種通常不會離開腸道的免疫細胞)逃逸,并且進入肝臟、脾臟等其他器官。

  為研究這一過程,加州大學戴維斯分校的Yaohui Sun和同事將小鼠的腸膜細胞置于電場中,以模擬受感染腸道。

  該團隊發現,在沒有沙門氏菌存在的情況下,幾乎所有巨噬細胞都向與腸道內部相對應的帶正電荷的區域移動。

  然而,在吞噬了與食物中毒有關的最常見的腸道沙門氏菌后,約41%的巨噬細胞逆轉方向,向帶負電荷的一端移動,這相當于離開腸道。

  Sun介紹說,研究發現,沙門氏菌擁有幫助其在巨噬細胞中存活的蛋白質,但并不清楚它是如何改變吸引巨噬細胞的電荷的。他認為,有可能是細菌釋放的酶破壞了巨噬細胞表面的電荷感應糖結構。

  佐治亞州埃默里大學的Sarah Fankhauser表示,最新發現有助于開發治療疾病的方法。這種機制不只在沙門氏菌中出現。例如,引起結核病的細菌也會通過巨噬細胞傳播,可能利用了類似策略。




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